10 Grown Organs in the Lab, Becoming Progress of Knowledge

Grown Organs by replanting lost limbs seem to be impossible when listening to them. However, recently several studies have mentioned satisfactory results for the restoration of limbs of animals and even humans. As was done by a team from Wake Forest University, who developed a cell biopsy in the bladder of a patient with spina bifida and used it to make a full-size bag. Then they implant it in the patient’s bladder. Cell biopsy still functions well after several years after implantation. With a note even though the bladder is emptied through a catheter. All of this proves that the field of medicine has progressed rapidly and lost limbs are not a big problem.

To renew an organ or limb that is perfect and complete is beyond the scope of human biology. However, researchers have developed various similar human limb structures that have been tested in several animals in the laboratory. To study the function and structure of organs or members of the human body, they start from a small scale called organoids. A substitution that is often seen found on the skin. Cells will be constantly replaced in the human body when worn out, this will make the process slow down with age but continue throughout human life.

Here are some examples of parts of grown organs in the laboratory?

There are indeed many challenges for researchers to reach a higher stage where they can replace lost body parts or create a list of artificial organs. But many researchers have developed this potential even further. It is truly amazing to see so far where science has developed rapidly. Here are some examples of parts of grown organs so far in the laboratory:

  1. Mini Heart Growth

Researchers at U.S. University have developed an animal heart, which is a rat that beats after rebuilding using human stem cells. Stimulates growing body parts from stem cells to develop into the heart muscle and connective tissue, then arrange them into small spaces so they can beat and this is what is called the Mini heart term. With that, it is possible to apply to humans using similar techniques.

By making human heart tissue that can be used in drug testing or for grafts to repair the damage. However, to replace the function of the entire human heart completely is not as easy as thought, using the beating of human heart tissue in the laboratory can be used to study heart disease and as a way to safely test new treatments.

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  1. Growing Fallopian Tubes

Scientists have grown the innermost cell layer of the human fallopian tubes using stem cells. The researchers described the resulting organoids as sharing a specific form for a full-size fallopian tube. This structure combines the ovaries and uterus in a woman’s body.

  1. Ears

Scientists have printed human ears in 3D, processing them by coating the shape of the ear formed with living cells that grow around the frame. The researchers created ear-shaped prints by modeling adult ears using 3D software and then sending the model to a 3D printer. After the scientists had fingerprints from their hands, they injected them with a mixture of living ear cells and collagen from cows.

Ear trials that are made are then implanted in mice for one to three months. It’s time they oversee this experiment and evaluate changes in size and shape as the grown organs. With this method, it is possible for the world of knowledge and health to help people with missing or disabled external ears.

  1. Mini Brain

It turned out that scientists had succeeded in creating a mini-brain that had been developed in a laboratory. The growing body parts on the brain is estimated to be “eraser” using skin cells. Structurally and genetically it is very similar to the brain of a nine-week-old human fetus. However, this mini-brain is not exactly the same as a real human brain. But the mini-brain has an organizational structure that is very comparable to real brains and active neurons.

  1. Minikidney Growth

Australian researchers grow the first mini kidney in a petri dish. By distinguishing stem cells to form organs with three types of kidney cells for the first time. This mini kidney is used for drug screening, disease modeling, and cell therapy. The researchers grew organoids in a process that follows normal kidney development.

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  1. Mini-lung

Researchers are trying to grow body parts of 3D lung organoids that develop airway structures and lung pockets. They conducted experiments on small animals. Because small animals can mimic real tissue responses and will be a good bodypart model for studying how organs form and change with disease, and how they respond to new drugs.

  1. Mini Stomach

The researchers experimented with stem cells that are used to make synthetic organs stomachs or Mini Stomachs. Mini Stomach was created to identify the factors needed to form a healthy human stomach and assist in the analysis of certain bacteria that cause stomach disease. Because bacteria behave differently in animal subjects. Jim Wells, one of the development biology professors at the Cincinnati Children’s Hospital Medical Center, said: “oval structures are oval-shaped, resembling one of two parts of the stomach”.

  1. Esophagus

Russian researchers build a functioning esophagus by growing stem cells on the scaffold. The scientists developed a new esophagus in the laboratory by implanting the organ in mice. The test was carried out by implanting an artificial structure in 10 mice and replaced to produce 20% of the animal’s original organs. The new esophagus is inflated and deflated it 10,000 times for durability.

  1. Liver Cells

The liver is one of the vital organs in the human body that is responsible for various functions and is able to carry out repairs and regeneration while in its place. However, science is making progress that makes scientists obsessed with growing body parts in liver cells. To grown organs liver cells, called hepatocytes and keep them alive, they are cultivated in the laboratory.

Recently, scientists announced that small organs, called liver buds, could be connected to the blood supply and function when transplanted into mice as an experiment. This technique is believed to be able to transplant thousands of these liver buds to human patients and help restore failed liver function. Although not a complete organ or organoid, this development will be something that is expected for the future and has promising implications for clinical studies.

  1. Vaginal Growth

A study described the success of a vaginal transplant that grows in a laboratory. This is evidence of grown organs in the lab. They managed to implant in four teenage girls who suffer from a rare genetic condition so they have genitals that are less developed. Evaluate congenital defects where the vagina and uterus are missing or underdeveloped. To ensure perfect tissue compatibility, use the patient’s own cells to produce unique results. Ensure that the vagina is the perfect size for every woman, using 3D biodegradable scaffolding like a tube to match each patient’s pelvic area. The results were in line with expectations, the patients gave a report that meant the vaginal organs were functioning normally.